In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component
نویسندگان
چکیده
منابع مشابه
In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component.
A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are invol...
متن کاملNew insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component.
Oleocanthal (OLC) is a phenolic component of extra-virgin olive oil, recently supposed to be involved in the modulation of some human diseases, such as inflammation and Alzheimer. In particular, OLC has been shown to abrogate fibrillization of tau protein, one of the main causes of Alzheimer neurodegeneration. A recent interpretation of this mechanism has been attempted on the basis of OLC reac...
متن کاملExtra virgin olive oil and oleic acid
For many decades, researchers have investigated the relationships between health status and consumption of extra virgin olive oil. Extra virgin olive oil (and oleic acid) is considered important for the prevention of coronary heart disease. While the biomolecular aspects involving G protein need further research, oleic acid levels in platelets may be a discriminating factor, together with linol...
متن کاملTherapeutic effects of phenolic compounds in extra virgin olive oil
Olive oil can be considered as a functional food because they carry a number of beneficial effects on the organism beyond nutritional benefits accepted. Studies conducted so far have shown that phenolic compounds in olive oil have positive effects on various physiological biomarkers, while exhibiting high bioavailability. Experimental studies (in vivo and in vitro) on phenolic compounds in oliv...
متن کاملUnusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal.
Oleocanthal, a major phenolic compound in extra-virgin olive oil with antiinflammatory properties, elicits an unusual oral pungency sensed almost exclusively in the throat. This contrasts with most other common oral irritants, such as cinnamaldehyde, capsaicin, and alcohol, which irritate mucus membranes throughout the oral cavity. Here, we show that this rare irritation pattern is a consequenc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2015
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1501000654